Can You Take Mounjaro and Metformin Together for Weight Loss?

mounjaro and metformin together weight loss

Combining pharmaceutical interventions for weight loss can be a game-changer for people struggling with obesity and related health conditions

Mounjaro (tirzepatide) is a relatively new medication, and metformin a well-established antidiabetic drug, has both been associated with weight reduction in certain circumstances.

This raises an important question for patients and healthcare providers alike: Is it safe to take Mounjaro and Metformin together for weight loss?

In this article, we’ll discuss whether it’s safe and effective to use Mounjaro and Metformin together, especially for weight loss.

Mounjaro (tirzepatide) is a cutting-edge medication for adults with type 2 diabetes. It’s an injectable prescription medicine that falls to a group of drugs known as GLP-1 receptor agonists.

This medicine works by acting like the hormones that help regulate blood sugar. It increases insulin release, decreases glucagon secretion, and slows down the process of emptying the stomach.

These actions help control blood sugar levels. Also, there are some studies that found tirzepatide can actually help with weight loss by curbing hunger and reducing our food intake.

But remember, it is primarily approved by the FDA for managing type 2 diabetes, not just for weight loss.

Note: It’s unclear if Mounjaro can be used in individuals who have had pancreatitis. Mounjaro is not suitable for those with type 1 diabetes. We don’t know if Mounjaro is safe and effective for children under 18 years old.

Must Read: How To Get Mounjaro 12 Month Coupon?

Side Effects of Mounjaro

While it serves its primary purpose efficiently, Mounjaro carries a risk of side effects. These can include:

  • Nausea and vomiting
  • Diarrhea
  • Reduced appetite
  • Constipation
  • Abdominal pain
  • Headaches
  • Fatigue or weakness
  • Dizziness

On rare occasions, Mounjaro can also cause more severe side effects like pancreatitis (inflammation of the pancreas), kidney problems, and low blood sugar (hypoglycemia).

If you experience any of these symptoms or other unusual side effects while taking Mounjaro, it’s curical to speak with your provider immediately.

What is Metformin?

Metformin is an FDA-approved drug that aids in managing elevated blood sugar levels in patients with type 2 diabetes.

It belongs to the class of drugs known as biguanides, Metformin works by decreasing glucose production in the liver, improving insulin sensitivity, and enhancing glucose uptake and utilization by the body’s tissues.

Controlling blood sugar levels using medications like metformin can help prevent problems like kidney damage, nerve issues, vision loss, amputations, and sexual problems.

Unlike many other diabetes medications, Metformin does not cause an increase in insulin secretion, resulting in a lower risk of hypoglycemia (low blood glucose levels).

Metformin is considered safe for most people with type 2 diabetes and is often prescribed for long-term use. Still, it’s not free from side effects.

While Metformin is primarily used for managing type 2 diabetes, its off-label use for weight loss in non-diabetic individuals has been an area of interest. However, it is not FDA-approved for this purpose.

Note: If you have kidney disease, acute or chronic metabolic acidosis (including diabetic ketoacidosis), it’s best to avoid taking Metformin. Before starting treatment, it’s crucial to assess renal function.

Side Effects of Metformin

Like any pharmaceutical, Metformin has its side effects:

  • Gastrointestinal discomfort
  • Nausea
  • Diarrhea
  • Bloating
  • Potentially decreased vitamin B12 levels
  • Headaches
  • Fatigue or weakness

In rare cases, Metformin can also cause more severe side effects like lactic acidosis, which can be life-threatening.

If you experience any unusual symptoms while taking Metformin, seek medical help immediately.

Related: Does BCBS Cover Mounjaro For Weight Loss

Is it safe to take Mounjaro and Metformin together for weight loss?

mounjaro and metformin together for weight loss

Yes, it’s totally safe to take Mounjaro and Metformin together for weight loss. Actually, combining them may even boost the weight loss effects for people with type 2 diabetes.

Clinical studies show that Mounjaro with its glucose-regulating properties and weight loss effects can be a great addition to Metformin.

Metformin already has benefits like improving insulin sensitivity and potentially helping with weight management. So, Mounjaro can be a helpful companion to Metformin.

However, it’s critical to note that any combined therapy should be closely checked by a doctor because it can cause additional side effects like stomach problems.

Currently, there is no solid evidence from big studies that confirms the long-term safety and effectiveness of this combination for weight loss in people without diabetes.

Patients must engage in a detailed discussion with their provider to weigh the potential risks against the benefits in their specific case.

Note: Further research is needed to establish the safety profile of concurrent use of Mounjaro and Metformin for weight loss, and this combination is not FDA-approved for people without diabetes.

Benefits of Taking Mounjaro and Metformin Together

For individuals with type 2 diabetes, the combination of Mounjaro and Metformin can translate into several potential benefits. These benefits are rooted in the complementary ways each drug works to improve blood sugar control and promote weight management:

1. Enhanced Glycemic Control: Both medications help in lowering blood glucose levels but through different mechanisms. Mounjaro increases insulin release and reduces glucagon secretion, improving blood sugar management. In contrast, metformin reduces glucose production in the liver and enhances insulin sensitivity. When used together, they may provide a more comprehensive approach to managing blood sugar.

2. Incremental Weight Loss: Studies show that when Mounjaro is taken with Metformin, patients may lose more weight than when using Metformin alone. This happens because Mounjaro helps reduce appetite and Metformin can either maintain weight or slightly reduce it.

3. Reduced Risk of Hypoglycemia: Unlike other medications for diabetes, Metformin has a lower chance of causing low blood sugar because it doesn’t directly stimulate insulin production.When combined with Mounjaro, which also helps regulate insulin release without causing low blood sugar, the risk is low while effectively managing blood sugar levels.

4. Complementary Side Effect Profiles: Both drugs have different side effects, which means they don’t amplify each other’s toxicities. When used together, their varying side effect profiles might balance out, potentially reducing the overall impact on the patient.

Possible Side Effects

Combining Mounjaro and Metformin is generally effective for managing type 2 diabetes and weight loss. However, it’s important to also know about potential side effects.

  • Gastrointestinal issues, like nausea or diarrhea, may be amplified when both medications are taken together.
  • The risk of hypoglycemia, while generally low, can still occur, especially if dietary intake is not well-managed or in conjunction with other diabetes medications.
  • Be careful when driving or operating any other machinery as the combination therapy may cause increased fatigue or dizziness.
  • Dehydration is a possible concern due to loss of appetite or mild diuresis caused by both medications. Remember to drink more fluids.
  • It’s important to regularly monitor kidney function as both drugs are processed through the kidneys and can affect renal performance over time.

Cautionary Advice

Before combining Mounjaro and Metformin, it’s important to know what should not be taken with each medication.

What should not be taken with Mounjaro?

There are some medications and substances that you should be used cautiously with Mounjaro due to potential interactions. These include:

  • Insulin and Insulin Secretagogues: Combining Insulin with Mounjaro may increase the risk of hypoglycemia. Dosage adjustments may be necessary for these medications.
  • Corticosteroids: These can increase blood glucose levels, counteracting the blood sugar-lowering effect of Mounjaro.
  • Diuretics: This may enhance diuretic-induced dehydration risk, warranting closer monitoring of fluid intake and hydration status.
  • Anti-hypertensive Agents: Mounjaro can lower blood pressure, potentially enhancing the effects of blood pressure medications, which may require adjustments.
  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs): They can affect kidney function, so combining them with Mounjaro should be done cautiously, considering Mounjaro’s renal excretion.

Note: This information is derived from FDA approval data and comprehensive medical resources to ensure accuracy and trustworthiness.

What should not be taken with Metformin?

Similarly, it’s important to be cautious about substances that may have a negative interaction with Metformin. These include:

  • Alcohol: Consuming excessive amounts of alcohol can raise the risk of lactic acidosis, especially when taking Metformin. So you need to avoid alcohol completely while taking Metformin. No need to take any risks.
  • Iodinated Contrast Media: These agents used in some radiologic studies can cause of post-contrast acute kidney injury. Usage of Metformin should be suspended before and after procedures involving such media to prevent renal issues.
  • Carbonic Anhydrase Inhibitors: Like  topiramate or zonisamide, can increase the risk of lactic acidosis when used with Metformin.
  • Other Antidiabetic Drugs: While not strongly discouraged, it is important to closely monitor the use of Metformin with sulfonylureas, thiazolidinediones, or insulin. This is because it may increase the risk of low blood sugar levels.


When using Mounjaro and Metformin together for managing type 2 diabetes and weight loss, it’s important to be aware of possible side effects and how it can interact with other medications.

Regularly checking blood sugar levels, kidney function, and overall health is very important for patients who are taking these medications together. With proper care and attention, Mounjaro and Metformin can be used as part of an effective treatment plan to enhance the quality of life for people with type 2 diabetes.


How can I speed up weight loss with Metformin?

Like Metformin, Mounjaro should be used along with a balanced diet and regular exercise. Eat whole foods that are nutrient-rich and stick to a consistent workout routine. It’s also helpful to consult a provider for personalized advice and consider combining Metformin with other weight management strategies.

How can I speed up weight loss with Mounjaro?

Like Metformin, Mounjaro should also be used in conjunction with a balanced diet and regular exercise. Eat balanced meals with lean proteins, veggies, and whole grains. Watch your calories. Exercise regularly with cardio and strength training. Consult your healthcare provider for personalized guidance.

How many kgs can you lose on Metformin?

On average, weight loss of 1 to 2 kgs is possible in the first few weeks. However, the total amount may vary based on factors like your diet, exercise, and how your body responds to the medication.


The information provided in this article is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Don’t ignore professional medical advice or put off seeking it just because of something you read here. Although we aim to offer precise and current information, we do not guarantee its completeness, accuracy, reliability, suitability, or availability for any purpose. Using the information in this document is at your own risk. We are not responsible for any losses or damages caused by our content.

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