GLP-1 medications such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have become very popular for helping people lose weight by reducing appetite and improving how the body handles food. Many patients prefer subscription-style plans because they include the prescription, medication delivery, and doctor support in one predictable monthly payment. These programs make ongoing treatment simpler than buying each pen separately at a pharmacy.
Subscription plans usually run through telehealth companies or specialized weight-loss clinics. They handle the initial consultation, dose titration, medication shipping, and follow-up messaging. Prices in 2025 range from about $199 to $499 per month for compounded versions, while branded options with insurance assistance can be much lower for eligible patients.
This article compares the main GLP-1 weight loss subscription plans available in 2025. It covers monthly costs, what is included, legitimacy and safety factors, typical results, and important things to consider before signing up. The information is based on current provider websites, patient reviews, and regulatory guidelines as of mid-2025.
How GLP-1 Subscription Plans Work
Most subscription plans start with an online intake form where you enter your height, weight, medical history, and weight-loss goals. A licensed physician or nurse practitioner reviews the information, often through a short video call or questionnaire. If approved, they write a prescription for compounded or branded GLP-1 medication.
The medication is compounded by a partnered pharmacy (usually 503A or 503B) or shipped as branded product when insurance or savings programs apply. The company mails the pen or vial to your home with syringes (if needed) and instructions. Follow-up visits or messaging support are included for dose adjustments and side-effect questions.
Plans charge one monthly fee that covers everything except any separate lab work your doctor may order. Some programs offer a money-back guarantee if the medication does not arrive or if you are not satisfied after the first month.
Branded vs Compounded Subscription Plans
Branded subscription plans use FDA-approved Ozempic, Wegovy, Mounjaro, or Zepbound. These are only available when you have commercial insurance that covers the drug and you qualify for the manufacturer’s copay card. Monthly out-of-pocket cost drops to $25–$50 for eligible patients, but the plan itself does not supply the medication—your local pharmacy fills the prescription.
Compounded subscription plans are the main option for uninsured patients or those with high deductibles. Telehealth companies partner with compounding pharmacies to create custom semaglutide or tirzepatide formulations. Prices are much lower ($199–$499/month) because there is no brand-name markup, but the product is not FDA-approved and quality depends on the pharmacy.
Branded plans offer guaranteed consistency and the strongest safety data. Compounded plans provide the lowest predictable monthly cost with built-in medical oversight for patients who cannot access branded coverage.
Comparison of Major GLP-1 Weight Loss Subscription Plans (2025)
| Provider / Plan Type | Monthly Cost Range (USD) | Medication Type | Includes Doctor Visits & Support? |
|---|---|---|---|
| Henry Meds | $247–$297 | Compounded semaglutide | Yes |
| Lavender Sky Health | $249–$349 | Compounded semaglutide / tirzepatide | Yes |
| Eden | $165–$299 | Compounded semaglutide | Yes |
| Mochi Health | $199–$399 | Compounded + branded options | Yes |
| Sesame Care | $249–$449 | Compounded + branded | Yes |
Compounded plans generally cost $199–$499/month all-inclusive. Branded coverage through insurance + savings card can be $25–$50 but requires qualifying commercial insurance.
Safety and Legitimacy Considerations
Compounded GLP-1 medications are not FDA-approved, so purity, potency, sterility, and consistency are not federally guaranteed. Reputable providers use 503B outsourcing facilities that follow current good manufacturing practices (cGMP) and provide third-party testing results for each batch.
Avoid companies that sell “research-use-only” peptides, ship without a prescription, or advertise unrealistically low prices ($99/month or less) without physician involvement. These sources carry higher risks of contamination, incorrect dosing, or lack of active ingredient.
Branded medications have the strongest safety profile and consistent quality control. If affordability is the only barrier, prioritize manufacturer patient assistance or discount cards for the FDA-approved product whenever possible.
Side Effects and How to Manage Them
Nausea is the most common side effect and usually peaks during dose increases. It often feels worse after larger or higher-fat meals. Vomiting occurs less often but can be more intense in the first 4–8 weeks.
Diarrhea, constipation, and abdominal discomfort alternate for some patients. Headaches and fatigue appear early as calorie intake drops suddenly. Injection-site reactions (redness, itching) are uncommon and temporary.
Most side effects improve significantly after the body adapts. Eating small, low-fat meals, avoiding lying down after eating, and staying hydrated help. Ginger tea or over-the-counter anti-nausea aids provide relief for many.
- Practical Management Tips:
- Eat very small portions on injection day
- Choose bland foods like rice or toast
- Sip ginger tea or chew mints
- Stay well hydrated throughout the day
Practical Steps to Start a GLP-1 Subscription Program
- Check eligibility for manufacturer patient assistance programs if uninsured (free medication for income-qualified patients).
- If commercially insured, activate copay cards before filling.
- Compare 3–5 reputable telehealth compounded providers. Ask about pharmacy source, sterility testing, physician oversight, and total fees.
- Schedule a virtual consultation and share recent labs (A1C, kidney function, lipids).
- Verify the provider is licensed in your state and uses a 503B facility.
- Start at the lowest dose and titrate slowly to minimize side effects.
- Track weight, waist, energy, and side effects weekly.
Long-Term Maintenance After Reaching Goal
Most patients regain a portion of lost weight after stopping GLP-1 medications unless strong habits are in place. Aim to maintain a high-protein diet (1.6–2.2 g/kg ideal body weight), strength training 2–3 times weekly, and 150 minutes of moderate activity.
Some providers offer lower maintenance doses to sustain appetite control at reduced cost. Transitioning to lifestyle-only management works best when calorie needs are recalculated at the new lower weight.
Regular follow-up with your clinician helps monitor blood pressure, lipids, and body composition. Many people find the habits formed during treatment become automatic over time.
GLP-1 weight loss subscription plans make treatment more convenient and affordable in 2025, especially through reputable compounded telehealth options ($199–$499/month) for uninsured patients. Branded coverage through insurance + savings cards can reduce costs to $25–$50/month for eligible individuals. Prioritize safety, licensed providers, and physician oversight to achieve sustainable results.
FAQ
What is the cheapest legitimate GLP-1 subscription plan without insurance?
The lowest monthly costs ($199–$349) typically come from reputable telehealth platforms offering compounded semaglutide or tirzepatide from 503B pharmacies. These all-inclusive fees cover consultation, prescription, medication, shipping, and follow-up visits. Manufacturer patient assistance can provide branded medication free for income-qualified uninsured patients.
Are compounded GLP-1 subscription programs safe?
Compounded versions are not FDA-approved, so quality varies. Choose providers that use 503B outsourcing facilities, provide third-party sterility and potency testing, require physician review, and offer ongoing support. Avoid companies selling “research peptides” or shipping without consultation.
Does the manufacturer give free GLP-1 medication to uninsured patients?
Yes. Novo Nordisk and Eli Lilly patient assistance programs provide free branded medication to uninsured or underinsured patients who meet income guidelines (typically ≤400% of the federal poverty level). Applications require proof of income and prescription. Approval takes 2–6 weeks.
Can GoodRx or similar cards lower GLP-1 costs without insurance?
Yes. GoodRx, SingleCare, RxSaver, and Blink Health frequently reduce branded semaglutide to $900–$1,100 per month at participating pharmacies. Some telehealth providers accept these cards for compounded versions, bringing costs even lower.
How do I know if an online GLP-1 subscription program is legitimate?
Look for licensed U.S. physicians, 503B pharmacies, third-party lab testing results, transparent pricing, and a money-back guarantee. Check recent independent reviews and verify state licensure. Avoid platforms that skip consultations or advertise unrealistically low prices without medical oversight.
What should I do if I cannot afford a GLP-1 subscription plan even with discounts?
Contact your prescribing doctor immediately. They can help apply for manufacturer patient assistance, switch to a lower-cost compounded option, adjust to a lower dose if appropriate, or prescribe an alternative medication with better financial support. Never stop treatment abruptly without medical guidance.
Dr. Usman is a medical content reviewer with 12+ years of experience in healthcare research and patient education. He specializes in evidence-based health information, medications, and chronic health topics. His work is based on trusted medical sources and current clinical guidelines to ensure accuracy, transparency, and reliability. Content reviewed by Dr. Usman is for educational purposes and does not replace professional medical advice.