Can I Take Berberine and L-Carnitine Together?

berberine and l carnitine

Berberine and L-carnitine are two popular dietary supplements known for their potential benefits in areas like weight management, heart health, and metabolic function.

Mostly people are concerned if they can be taken together to amplify these benefits. It’s important to understand how these supplements might interact and work together when taken at the same time, as they each have their own unique properties.

This article aims to provide you with the outcomes of taking Berberine and L-Carnitine together, with a focus on safety, efficacy, and potential health outcomes.

What is A Berberine?

Berberine is a bioactive compound that is extracted from different plants, including a group of shrubs called Berberis. Traditionally used in Chinese medicine, it’s now recognized for its benefits in modern medicine too.

Berberine has been found to have anti-inflammatory and anti-diabetic effects, and it can also positively impact heart health. Moreover, it’s been found to aid in weight loss and can improve the body’s metabolism.

It could also have other advantages and help with conditions like depression and nonalcoholic fatty liver disease (NAFLD).

However, it’s important to note that while berberine has many potential benefits, it can interact with certain medications, and some people may experience side effects.

Side effects

Some of the possible side effects associated with berberine include:

  • Digestive discomfort
  • Nausea
  • Diarrhea
  • Constipation
  • Low blood pressure
  • Skin rash
  • Headache
  • Flatulence
  • Cramping

Berberine is generally safe with minimal side effects, but it’s always a good idea to consult a doctor before using it.

Related: Can You Take Berberine And Magnesium Together?

What is L-carnitine?

L-carnitine is a naturally occurring amino acid derivative that’s often taken as a weight loss supplement. It plays a key role in the production of energy by transporting fatty acids into your cells’ mitochondria. The mitochondria act as engines within your cells, burning these fats to create usable energy.

People’s bodies can produce L-carnitine from the amino acids lysine and methionine. For this reason, it is mostly categorized as a conditionally essential nutrient. Its presence is particularly concentrated in tissues that utilize fatty acids as a dietary fuel, like skeletal and cardiac (heart) muscle.

L-carnitine is also found to have benefits in various health aspects. It could potentially improve exercise performance and muscle recovery, support heart health, and manage symptoms in different neurological conditions.

Nonetheless, like all supplements, L-carnitine also has a potential for side effects, especially when taken in high doses.

Related: 9 Amazing L-Carnitine Benefits for Females

Side Effects

Possible side effects of L-carnitine can include:

  • Nausea
  • Vomiting
  • Stomach discomfort
  • Heartburn
  • Diarrhea
  • Seizures
  • Weakness

While generally safe for most people when used as directed, it’s recommended to consult a doctor before adding L-carnitine to your routine.

Can I take Berberine and L-carnitine together?

Yes, you can take Berberine and L-carnitine together, as they are not known to interact negatively with each other. Some studies have shown that taking these two supplements together can potentially enhance their individual

Berberine’s potential to regulate glucose metabolism and improve insulin sensitivity may complement L-carnitine’s role in fatty acid transportation and energy production.

This mix could help with weight control and boost metabolism. But remember, both supplements can cause stomach issues, so taking them together might make these side effects worse.

On the other hand, when you take both of these supplements, they might have a positive effect on your heart health. Berberine helps protect your heart, while L-carnitine helps produce energy. Together, they could improve how your heart works.

However, while these potential benefits are promising, it’s important to consult a professional before adding this to your routine.

This is especially important if you’re taking medication, as berberine can interact with certain drugs. We also need more research to confirm if it’s safe and effective to combine Berberine and L-carnitine.

Also Read: Does Berberine Change Your Stool Color?

L-carnitine and Berberine Together Benefits

When taken together, Berberine and L-carnitine can provide many potential benefits:

  1. Weight Management: Both Berberine and L-carnitine have been linked with weight loss and improved metabolic function. When combined, they may enhance these effects, potentially leading to better weight management outcomes.
  2. Improved Metabolic Function: Berberine’s ability to regulate glucose metabolism and improve insulin sensitivity coupled with L-carnitine’s role in fatty acid transportation and energy production may lead to overall improved metabolic function.
  3. Enhanced Heart Health: Both supplements have heart health benefits – Berberine has been found to positively impact heart health, while L-carnitine supports energy production that is essential for the heart’s functioning.
  4. Synergistic Effects: Some research suggests that taking these two supplements together may result in a synergistic effect, enhancing the individual benefits of each supplement.

Possible side Effects

While combining Berberine and L-carnitine offers potential benefits, it’s essential to consider possible side effects.

Both supplements individually can cause gastrointestinal issues, like nausea, diarrhea, and stomach discomfort. When taken together, these effects may be amplified.

Moreover, high doses of L-carnitine might cause more severe problems like seizures or muscle weakness. Berberine, on the other hand, can lower blood pressure and may cause a skin rash or headache in some people.

It’s also crucial to remember that Berberine can interact adversely with certain medications like antibiotics, antidepressants, and blood pressure medications.

It’s a good idea to talk to a doctor before starting any new supplements, especially if you’re taking medication.

Must Read: Can Berberine Really Damage the Liver?

What should not be taken with L-carnitine?

While L-carnitine is generally safe to consume, there are certain substances that might interact adversely with it:

Thyroid Medications: L-carnitine might decrease how well thyroid hormone replacements work. If you’re on thyroid medication, consult with your doctor before taking L-carnitine.

Valproic Acid (Depakote): There are reports of this epilepsy medication causing severe liver toxicity when taken with L-carnitine. Do not take L-carnitine if you’re on Depakote.

Anticoagulants: Since L-carnitine has blood-thinning properties, it may interact with anticoagulant medications and increase the risk of bleeding.

Chemotherapy Drugs: Some research suggests that L-carnitine might interfere with the effectiveness of certain chemotherapy drugs.

What should not be taken with Berberine?

Berberine is generally safe for most people, but it can interact with certain medications and substances. There are certain things you should avoid when taking Berberine, including:

Anticoagulant Medications: Berberine may increase the risk of bleeding when taken with anticoagulant drugs, like warfarin and heparin.

Antidiabetes Drugs: Berberine can lower blood sugar levels. When taken with antidiabetes drugs, it may cause blood sugar levels to plummet dangerously low, leading to hypoglycemia.

Cyclosporine: Cyclosporine is an immunosuppressant drug. The use of berberine with cyclosporine can reduce the drug’s effectiveness, potentially leading to transplant rejection or other serious complications.

Blood Pressure Medications: Berberine can also lower blood pressure. When it is used in combination with antihypertensive medications, it can cause blood pressure to be too low, leading to dizziness, fainting, and other complications.

Macrolide Antibiotics: Berberine can block the body’s ability to break down certain antibiotics in the macrolide family, like erythromycin and clarithromycin. This could lead to an increase in antibiotic side effects.


In conclusion, the combination of Berberine and L-carnitine may offer a lot of health benefits, such as weight management, enhancing metabolic function, improving heart health, and potentially creating a synergistic effect that amplifies their benefits. However, these benefits need to be weighed against possible side effects, especially gastrointestinal issues and potential interactions with other medications. Before taking any nutritional supplements, it’s important to consult with a healthcare professional to make sure they’re right for you.


What is L-carnitine Best Taken With?

If you are looking to enhance the potential benefits of L-carnitine, you may consider combining it with a well-balanced diet, regular exercise, and other supportive supplements like omega-3 fatty acids or coenzyme Q10.

Can You Mix L-carnitine with Other Supplements?

Yes, L-carnitine can be mixed with other supplements. One common combination is L-carnitine with Omega-3 fatty acids, which together, may support healthy heart function, help in weight management, and enhance physical performance. Combining L-carnitine with Coenzyme Q10 can be beneficial. They both help in energy production and have antioxidant properties.

Is L-carnitine Effective for Weight Loss in PCOS?

Polycystic ovary syndrome (PCOS) is a complex hormonal condition that may contribute to weight management challenges. While L-carnitine may have potential benefits for overall metabolism and energy production, its effectiveness specifically for weight loss in people with PCOS requires further research.


The information provided in this article is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Don’t ignore professional medical advice or put off seeking it just because of something you read here. Although we aim to offer precise and current information, we do not guarantee its completeness, accuracy, reliability, suitability, or availability for any purpose. Using the information in this document is at your own risk. We are not responsible for any losses or damages caused by our content.

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