Can I Take Tylenol or Ibuprofen with Paxlovid?

Can I Take Tylenol or Ibuprofen with Paxlovid

Paxlovid is a novel antiviral medication developed by Pfizer. It has recently received broad attention due to its potential effectiveness against COVID-19.

As with any new medication, questions arise regarding its interaction with common over-the-counter drugs like Tylenol (acetaminophen) and Ibuprofen.

Understanding these interactions is important for patients aiming to manage side effects or concurrent health conditions while undergoing treatment. This article will delve into the possible interactions between Paxlovid and these commonly used medications.

What Is Paxlovid And Its Main Purpose?

Paxlovid, also known as PF-07321332, is a protease inhibitor developed by Pfizer. It works by stopping the function of an enzyme that the SARS-CoV-2 virus, which causes COVID-19, needs to replicate within a human host.

This medication’s primary purpose is to treat mild-to-moderate COVID-19 in adults who have tested positive for the virus and are at high risk for progressing to severe COVID-19, including hospitalization or death.

It is administered orally, in combination with ritonavir, another drug that boosts the effect of Paxlovid. As for interactions with over-the-counter drugs, always consult your healthcare provider for accurate information and guidance.

Can I take Tylenol or Ibuprofen with Paxlovid?

According to Pfizer, it is safe to use over-the-counter pain relievers like Tylenol (acetaminophen) or Ibuprofen with Paxlovid. No specific warnings have been given against their simultaneous use.

However, this does not mean that there could not be individual considerations based on a patient’s unique health circumstances.

Interaction of Paxlovid with Tylenol

Tylenol is also commonly known as acetaminophen. It is a common over-the-counter pain reliever and fever reducer.

According to Pfizer, there have been no reported negative interactions between Paxlovid and Tylenol. This suggests that it’s likely safe for patients to take these two medications concurrently.

However, it’s worth noting that both Paxlovid and Tylenol are metabolized in the liver. Therefore, people with liver conditions or those taking other medications that affect liver function should consult with a provider before combining these drugs.

Interaction of Paxlovid with Ibuprofen

Ibuprofen, sold under brands like Advil and Motrin, is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain.

Pfizer hasn’t given any special warnings or precautions about using ibuprofen with Paxlovid. So, it’s generally safe to use ibuprofen while taking Paxlovid.

However, since ibuprofen is also processed in the liver, people with liver problems or those taking medications that affect liver function should talk to their doctor before using them together.

Furthermore, it is important to note that while these over-the-counter drugs can alleviate some symptoms of COVID-19, they do not treat the virus itself. Therefore, they should not be used as a substitute for proper medical treatment for COVID-19.

Also Read: Does Ibuprofen Help Globus Sensation? Complete Guide

Potential Interactions of Paxlovid

Here are some potential interactions to consider when using Paxlovid with other medications:

  • Antiviral drugs: Combining multiple antiviral medications could lead to increased side effects and decreased effectiveness.
  • Blood-thinning medications: Since Paxlovid can increase the risk of bleeding, combining it with other blood-thinning medications should be done with caution and under the guidance of a provider.
  • Medications that affect liver function: As mentioned earlier, both Paxlovid and over-the-counter drugs like Tylenol and Ibuprofen are metabolized in the liver. Therefore, combining these drugs with other medications that also impact liver function could cause complications.
  • Medications that suppress the immune system: Paxlovid works by blocking the process necessary for virus replication, which could also have an impact on the immune system. Combining it with other medications that suppress the immune system could lead to decreased effectiveness against COVID-19 or an increased risk of infections.

Safety Considerations

When taking any medication, including Paxlovid, it’s important to consider general safety precautions.

  • Always consult with a healthcare provider before adding new medications to your treatment regimen.
  • Follow the recommended dosage and do not exceed the prescribed amount.
  • Be aware of potential side effects and report any concerning symptoms to your doctor immediately.
  • Disclose all current medications, supplements, and medical conditions to your healthcare provider to avoid potential interactions.
  • Do not stop taking Paxlovid or any other medication without consulting with your doctor first.


When it comes to the interaction between Paxlovid and Tylenol or ibuprofen, it is important to prioritize your safety and well-being. While Pfizer has shown that there are no known negative interactions between Paxlovid and common over-the-counter medications like Tylenol (acetaminophen) and Ibuprofen, individual health circumstances may dictate otherwise.

If you have any liver conditions or are taking other liver-impacting drugs, it’s important to consult a professional before combining Paxlovid and over-the-counter medications.


How long after taking paxlovid will i test negative for Covid?

There is no definitive timeline as to when you will test negative for COVID-19 after taking Paxlovid. The medication is intended to reduce the severity of symptoms and complications, not necessarily to speed up the recovery process. The timing can vary based on your health circumstances and the severity of the infection.

Can I take Paxlovid with Panadol?

Yes, you can take Paxlovid with Panadol (acetaminophen). Pfizer has not reported any negative interactions between Paxlovid and Panadol. However, if you have a liver condition or are taking other medications that affect liver function, it’s important to talk to your professional before combining these drugs.

Can you take aleve with paxlovid?

Yes, it is generally safe to take Aleve (naproxen) with Paxlovid. Pfizer has not specified any interactions between Paxlovid and Aleve. However, like Tylenol and ibuprofen, Aleve is also metabolized in the liver. Therefore, those with liver conditions or those taking other medications affecting liver function should consult with a healthcare provider before using them together.

Can I drink alcohol while taking paxlovid?

No, you can’t take paxlovid with alcohol as it can increase the risk of side effects and decrease effectiveness. It is generally advised to avoid or limit alcohol when taking any medication. Alcohol can increase the risk of liver damage, especially since Paxlovid is metabolized in the liver.

Can i take benadryl with paxlovid?

Yes, it is generally considered safe to take Benadryl (diphenhydramine) with Paxlovid. There are no specific warnings or precautions from Pfizer regarding the use of these two medications together. However, it is recommended to consult with your doctor before combining medications. This is because Benadryl can cause drowsiness, and when combined with Paxlovid, it could potentially amplify this effect.

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The information provided in this article is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Don’t ignore professional medical advice or put off seeking it just because of something you read here. Although we aim to offer precise and current information, we do not guarantee its completeness, accuracy, reliability, suitability, or availability for any purpose. Using the information in this document is at your own risk. We are not responsible for any losses or damages caused by our content.

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