Can Semaglutide Affect Your Period? Everything You Need to Know

Can Semaglutide Affect Your Period

Semaglutide is a medication that is commonly used for the treatment of type 2 diabetes. It also has proven its efficacy in managing blood sugar levels.

However, like most medications, it may also come with some potential side effects. When deciding to start Semaglutide, this is a crucial consideration for women. They often wonder if Semaglutide can impact their menstrual cycle.

In this article, we aim to explore this question, shedding light on the connection between Semaglutide and menstrual irregularities, and providing the information you need to ensure your health and well-being while on this medication.

Understanding What is Semaglutide?

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. This medication also known as incretin mimetics, is designed to regulate blood sugar levels in individuals with type 2 diabetes. It works by helping our pancreas to release insulin when blood sugar levels are high. This insulin helps transfer sugar from the blood to other body tissues for energy.

Available under brand names like Ozempic and Rybelsus, Semaglutide can be a key part of a comprehensive diabetes management plan. Besides its primary function, Semaglutide has also been found effective in helping weight loss which makes it a good tool in managing both diabetes and obesity.

However, as with any medicine, understanding its potential side effects is crucial. In the next sections, we will discuss whether and how Semaglutide could affect your period.

Related: How To Reconstitute Semaglutide: A Complete Guide 

Can Semaglutide affect your period?

Yes, Semaglutide can potentially affect your period. As per reports from patients and observations from healthcare providers, Semaglutide can lead to alterations in the menstrual cycle. Some women have reported changes in the regularity, duration, and intensity of their periods, with some experiencing heavier or lighter periods than usual.

As you know Semaglutide helps people with diabetes control their blood sugar, so any changes in blood sugar levels can impact your menstrual cycle. And, by the way, blood sugar and periods are actually connected.

Ovulation happens around the middle of your menstrual cycle. During this time, your body produces more progesterone which can make your body less responsive to insulin. This may lead to high blood sugar levels and hyperglycemia.

However, it’s important to remember that everyone’s body reacts differently to medication, and not all women taking Semaglutide will experience these menstrual changes. It’s also worth noting that irregular periods can be a result of other factors, like stress, weight changes, or other underlying health conditions.

Therefore, if you notice changes to your menstrual cycle after starting Semaglutide, it’s important to consult with your doctor to discuss this side effect and determine the best course of action.

Also Read: Does wegovy affect menstrual cycle? Uncover the Truth

Can Semaglutide Cause Irregular Periods?

Yes, Semaglutide may cause irregular periods. As mentioned earlier, the drug can cause alterations in the menstrual cycle, which includes irregularities.

However, based on recent research from clinical trials, there isn’t clear evidence to support the claim that Semaglutide causes menstrual irregularities.

It might be related to the hormonal changes brought about by fluctuations in blood sugar levels, or it could be a direct impact of the drug on the menstrual cycle.

In contrast, losing a lot of weight quickly can also mess up your periods.

Losing too much weight can make your periods stop and restrict too many calories, which can prevent the production of hormones needed for ovulation [1]. GLP-1 medications like Ozempic and Wegovy which have Semaglutide can indirectly affect your menstrual cycle.

However, remember that not every woman who takes Semaglutide will experience these changes. If your periods become irregular after starting Semaglutide, reach out to your doctor to determine if the drug is the cause and to explore potential solutions.

Must Read: Does Semaglutide Cause Hair Loss? Complete Guide

Can Semaglutide cause you to miss your period?

Can Semaglutide cause you to miss your period

Yes, there have been instances where Semaglutide has caused women to miss their periods. This can be a distressing experience for women who aren’t expecting such changes.

The hormone fluctuations caused by alterations in blood sugar levels, as well as the potential stress of managing a chronic condition like diabetes, can all impact menstrual regularity.

Furthermore, significant weight loss, which is a common effect of Semaglutide, can also lead to missed periods. This is because drastic changes in body weight can disrupt the balance of hormones that regulate menstruation.

If you’ve started taking Semaglutide and have missed a period, it’s important to communicate this to your doctor.

Also Read: Why Am I Still Hungry on Semaglutide? Unveiling The Truth 

How can you prevent a missed period on Semaglutide?

Besides menstrual changes, rapid weight loss can also lead to fatigue, hair loss, facial changes, and changes in the buttocks.

To prevent a missed period while on Semaglutide, focus on maintaining good health and well-being. Here are some strategies to consider:

Maintain a healthy body weight

Significant weight fluctuations can disrupt your menstrual cycle. If you’re using Semaglutide for weight loss, aim for a slow, steady speed rather than drastic, quick weight loss. Regular exercise and a balanced diet can help in maintaining a healthy weight.

Regulate your blood sugar levels

Abnormal blood sugar levels can cause hormonal changes that can impact your menstrual cycle. Regularly monitoring and managing your blood sugar levels can help prevent any disruptions.

Stress Management

High levels of stress can also impact your menstrual cycle. It is recommended to incorporate stress-management techniques, such as yoga, meditation, or mindfulness, into your daily routine to help manage and reduce stress.

Regular Check-ups

Regular health check-ups with your doctor are crucial while being on Semaglutide. They can help in early detection if the medication is causing changes in your menstrual cycle and adjust your treatment plan accordingly.

Watch your diet

When using Semaglutide, your body may need to adjust to consuming fewer calories. To effectively solve this issue and ensure sufficient time for your body to adapt, it is important to maintain a nutritious and well-balanced diet. Aim for foods that are rich in iron, calcium, and vitamin D as these nutrients are essential for maintaining a regular menstrual cycle.

Does Semaglutide affect hormones?

Yes, Semaglutide can affect hormones in your body. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, a type of drug that mimics the effects of GLP-1, a hormone in the body.

GLP-1 is produced by your digestive system in response to meals. It helps lower blood sugar by increasing insulin production and release from the pancreas while reducing glucose production by the liver.

For women with PCOS who produce excessive insulin, this can also lead to an overproduction of androgens in the ovaries and impact other hormones related to female reproductive health [2].

The connection between GLP-1 and reproductive hormones is not yet fully understood, but there is evidence that GLP-1 can affect the function of the ovaries, which produce the hormones that regulate menstruation.

So, it’s possible that Semaglutide, by acting like GLP-1, could mess with these hormones and potentially cause some changes in menstruation.

Common side effects of Semaglutide

Like all medications, Semaglutide may have side effects. Common side effects that most people experience are generally mild and tend to dissipate as your body adjusts to the medication, which generally affects 10% of people taking Semaglutide. These include:

  1. Nausea
  2. Vomiting and Diarrhea
  3. Loss of appetite
  4. Abdominal Pain
  5. Fatigue
  6. Constipation

Serious side effects are less common but can occur. If you experience any of the following symptoms, you should contact your doctor immediately:

  1. Severe stomach pain: This could be a sign of pancreatitis, a serious condition that requires immediate medical attention.
  2. Changes in vision: Semaglutide can sometimes cause low blood sugar, which can cause vision changes.
  3. Mental mood changes: This includes symptoms like confusion, difficulty concentrating, or unusual mood swings.
  4. Signs of kidney problems: Such as changes in the amount of urine.
  5. Severe nausea, vomiting, or diarrhea: If these symptoms persist, they can lead to dehydration, which is a serious condition needing immediate medical attention.
  6. Signs of an allergic reaction: Such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing.

Just a reminder, this list doesn’t cover all possible side effects. If you experience any other effects not mentioned, make sure to reach out to your doctor right away.

Should I stop Semaglutide if it impacts my menstruation?

If Semaglutide significantly affects your menstruation, it is essential that you do not stop taking the medication without consulting your doctor.

Stopping Semaglutide suddenly can potentially worsen your condition and harm your health. If you’re experiencing changes in your menstrual cycle, it’s crucial to communicate this to your healthcare provider. They can help to evaluate the situation and adjust your treatment plan if necessary. This could mean changing your dosage or switching to a different medication.

Plus, they can rule out other potential causes for menstrual irregularity, like stress or a hormonal imbalance.


In conclusion, yes, semaglutide can affect your period. But the extent to which it does varies from person to person and depends on several factors such as hormone levels and weight loss. If you have concerns about your menstrual cycle while taking semaglutide, make sure to discuss them with your doctor. They can help you find the best solution for managing your diabetes and any potential side effects.



The information provided in this article is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Don’t ignore professional medical advice or put off seeking it just because of something you read here. Although we aim to offer precise and current information, we do not guarantee its completeness, accuracy, reliability, suitability, or availability for any purpose. Using the information in this document is at your own risk. We are not responsible for any losses or damages caused by our content.

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