Jardiance, known generically as empagliflozin, serves as a prescription medication primarily for adults with type 2 diabetes. It helps control blood sugar levels when combined with diet and exercise. Beyond diabetes, doctors prescribe it for heart failure and chronic kidney disease to lower risks of serious complications.
Many patients wonder about increased urination as a potential issue with this drug. The answer is yes—Jardiance often leads to more frequent trips to the bathroom. This happens because of how the medication functions in the body, prompting the kidneys to remove extra sugar through urine.
This article explores Jardiance’s workings, its benefits, common side effects including urination changes, and ways to handle them. You’ll also find a comparison to similar drugs and practical advice. By the end, an FAQ section addresses key questions.
What Is Jardiance and Who Should Take It?
Jardiance belongs to a class of drugs called SGLT2 inhibitors. These medications target the kidneys to manage blood sugar. Approved by the FDA, it’s available in 10 mg and 25 mg tablets taken once daily.
People with type 2 diabetes use it to improve glycemic control. It’s also for those with heart failure to reduce hospitalization risks. Additionally, it helps adults with chronic kidney disease at risk of progression.
Doctors consider it for patients needing better heart or kidney protection. It’s not for type 1 diabetes or diabetic ketoacidosis. Always consult a healthcare provider before starting.
How Does Jardiance Work?
Jardiance blocks the SGLT2 protein in the kidneys’ proximal tubules. This protein normally reabsorbs glucose back into the blood. By inhibiting it, the drug allows excess sugar to exit via urine.
This process lowers blood glucose levels effectively. It also promotes mild weight loss as calories leave with the sugar. The mechanism provides cardiovascular benefits by reducing strain on the heart.
In heart failure, it decreases fluid buildup through natriuresis. For kidney disease, it slows progression by easing pressure in the glomeruli. Overall, it shifts energy use in the body for better organ function.
Why Does Jardiance Cause More Frequent Urination?
The core action of Jardiance involves increasing glucose in the urine. This draws more water into the bladder, leading to higher urine volume. Studies show an average increase of about 300-400 mL per day initially.
This effect starts soon after the first dose. It may lessen slightly over time as the body adjusts. However, many users report urinating 8-12 times daily, including at night.
Dehydration can worsen if not managed. Drinking extra fluids helps. This side effect ties directly to the drug’s benefits in lowering blood sugar.
Benefits of Jardiance Beyond Blood Sugar Control
Jardiance reduces the risk of cardiovascular death by up to 38% in diabetic patients with heart disease. It cuts hospitalization for heart failure by 25%. These outcomes come from large clinical trials.
For kidney health, it slows decline in eGFR and prevents end-stage disease. It works even in non-diabetics with heart failure. Weight loss averages 2-3% of body weight over time.
It may lower blood pressure slightly due to fluid loss. These advantages make it a versatile option for multifaceted health issues. Patients often see improved quality of life.
Common Side Effects of Jardiance
Besides increased urination, Jardiance can cause urinary tract infections. Symptoms include burning during urination and frequent urges. Yeast infections affect genitals due to sugar in urine.
Dehydration signs like thirst or dizziness occur if fluid intake lags. Some experience joint pain or nausea early on. Low blood pressure might cause lightheadedness when standing.
Rare but serious issues include ketoacidosis with symptoms like abdominal pain. Allergic reactions are uncommon but possible. Monitoring helps catch issues early.
- Urinary tract infections: Affect up to 7% of users.
- Genital yeast infections: More common in women.
- Increased thirst: Linked to fluid loss.
- Nausea: Usually mild and temporary.
Comparing Jardiance to Other SGLT2 Inhibitors
Jardiance shares similarities with drugs like Farxiga and Invokana. All increase urination as part of their action. However, differences exist in approved uses and outcomes.
Farxiga excels in heart failure across ejection fractions. Invokana may offer stronger kidney protection in some studies. Jardiance stands out for cardiovascular death reduction.
Here’s a comparison:
| Medication | Increases Urination? | Primary Benefits |
|---|---|---|
| Jardiance | Yes | Blood sugar control, heart death risk reduction, kidney protection |
| Farxiga | Yes | Heart failure hospitalization reduction, CKD progression slowdown |
| Invokana | Yes | Diabetes management, strong renal benefits, weight loss aid |
This table highlights key aspects.
Managing Increased Urination and Other Side Effects
Stay hydrated by aiming for 8-10 glasses of water daily. This counters dehydration from extra peeing. Avoid caffeine and alcohol, which worsen the urge.
For infections, practice good hygiene like wiping front to back. Wear cotton underwear to reduce moisture. Over-the-counter remedies may help mild yeast issues.
Track symptoms and report persistent ones to your doctor. Dose adjustments aren’t common, but alternatives exist if needed. Lifestyle tweaks ease most effects.
- Drink water proactively throughout the day.
- Use absorbent pads if nighttime urination disrupts sleep.
- Eat a balanced diet to support overall health.
- Exercise regularly to enhance benefits.
When to Consult Your Doctor
See a doctor if urination becomes excessive or painful. Signs of UTI like cloudy urine warrant prompt attention. Persistent thirst or fatigue may signal dehydration.
Watch for ketoacidosis symptoms such as vomiting or confusion. Leg sores or infections need immediate care. Any allergic reaction requires emergency help.
Regular check-ups monitor kidney and heart function. Discuss all medications to avoid interactions. Open communication ensures safe use.
Conclusion
Jardiance offers significant advantages for managing diabetes, heart failure, and kidney disease, despite the common side effect of increased urination. By understanding its mechanism and taking proactive steps, most people handle it well. Always weigh benefits against risks with your healthcare team for personalized care.
FAQ
How soon does increased urination start with Jardiance?
It often begins within the first day or two of starting the medication. The body expels more glucose and water right away. This peaks early but may stabilize over weeks.
Can Jardiance cause weight loss?
Yes, many lose 2-5% of body weight due to calorie loss in urine. It’s not a weight loss drug, but this helps diabetes management. Combine with diet for best results.
Is Jardiance safe for long-term use?
Studies show it’s safe for years with monitoring. Benefits for heart and kidneys persist. Regular blood tests check for issues like dehydration or infections.
What if I miss a dose of Jardiance?
Take it as soon as you remember, unless near the next dose. Skip if close and resume normally. Don’t double up to avoid side effects.
Does Jardiance interact with other medications?
It can with diuretics, increasing dehydration risk. Insulin may heighten low blood sugar chances. Discuss all drugs with your doctor for adjustments.
Can Jardiance be used in non-diabetics?
Yes, for heart failure or chronic kidney disease. It reduces hospitalization and progression risks. Benefits apply regardless of diabetes status.
Dr. Usman is a medical content reviewer with 12+ years of experience in healthcare research and patient education. He specializes in evidence-based health information, medications, and chronic health topics. His work is based on trusted medical sources and current clinical guidelines to ensure accuracy, transparency, and reliability. Content reviewed by Dr. Usman is for educational purposes and does not replace professional medical advice.