GLP-1 receptor agonists have become essential tools for managing type 2 diabetes and supporting chronic weight loss in eligible adults. These medications help by mimicking natural gut hormones to control appetite, slow digestion, and stabilize blood sugar. Proper dosing ensures effectiveness while keeping side effects manageable.
Dosing follows a careful titration process, starting low to allow the body to adapt before reaching maintenance levels. This gradual approach reduces common issues like nausea and improves long-term adherence. In 2026, FDA-approved schedules remain consistent across major brands.
This article provides clear dosing charts, explanations of titration steps, and practical advice. Information draws from official guidelines and clinical standards. Always follow your healthcare provider’s instructions, as individual adjustments may apply based on response and tolerance.
Understanding GLP-1 Receptor Agonists
GLP-1 agonists include semaglutide, tirzepatide, dulaglutide, and liraglutide, available under brands like Wegovy, Zepbound, Trulicity, and Victoza. They primarily treat type 2 diabetes, with several approved for obesity. Weekly injections dominate, though one oral option exists.
These drugs promote satiety, reduce calorie intake, and offer cardiovascular benefits. For weight loss, they achieve 15-22% average body weight reduction in trials at full doses. Dosing varies by brand, indication, and patient factors.
Titration protects against gastrointestinal side effects that often occur early. Providers monitor progress and adjust as needed. Consistency with the schedule supports optimal results.
GLP-1 Dosing Chart
GLP-1 dosing charts outline starting amounts, escalation steps, and maintenance levels for each medication. Schedules typically span 16-20 weeks to reach full therapeutic doses.
Wegovy (semaglutide for weight loss) begins at 0.25 mg weekly for four weeks, then increases every four weeks to 0.5 mg, 1 mg, 1.7 mg, and finally 2.4 mg. This pattern minimizes discomfort while building efficacy.
Zepbound (tirzepatide) starts at 2.5 mg weekly for four weeks, then steps up in 2.5 mg increments every four weeks to a maximum of 15 mg. Dual action often leads to robust appetite suppression. Ozempic (semaglutide for diabetes) follows a similar path but caps at 2 mg weekly.
Semaglutide-Based Dosing (Wegovy and Ozempic)
Wegovy titration:
Weeks 1-4: 0.25 mg weekly
Weeks 5-8: 0.5 mg
Weeks 9-12: 1 mg
Weeks 13-16: 1.7 mg
Week 17 onward: 2.4 mg maintenance (if tolerated)
Ozempic (often used off-label for weight):
Weeks 1-4: 0.25 mg
Weeks 5-8: 0.5 mg
Week 9+: 1 mg, then up to 2 mg if needed for glycemic control
Missed doses should resume at the current level if within five days; otherwise, consult a provider. Weekly consistency maintains steady drug levels.
Tirzepatide Dosing (Zepbound/Mounjaro)
Standard schedule:
Weeks 1-4: 2.5 mg weekly
Weeks 5+: 5 mg (minimum four weeks)
Subsequent increases: 7.5 mg, 10 mg, 12.5 mg, 15 mg (each step at least four weeks)
Many reach effective maintenance at 10-15 mg. Providers may hold or reduce if side effects persist. Dual GLP-1/GIP action enhances results compared to single agonists.
Other GLP-1 Agonists (Trulicity, Victoza, Rybelsus)
Trulicity (dulaglutide): Starts at 0.75 mg weekly, increases to 1.5 mg after four weeks, up to 4.5 mg maximum.
Victoza (liraglutide): Begins at 0.6 mg daily for one week, then 1.2 mg daily, up to 1.8 mg (or 3 mg for weight in Saxenda form).
Rybelsus (oral semaglutide): Starts at 3 mg daily for 30 days, then 7 mg, up to 14 mg daily.
These offer alternatives for those preferring daily dosing or oral administration. Titration remains gradual across the class.
Comparison of GLP-1 Dosing Schedules
Here’s a table summarizing key GLP-1 medications, their starting doses, titration steps, and maintenance levels for weight loss or diabetes use.
| Medication | Starting Dose | Titration Interval & Steps | Maximum/Maintenance Dose | Primary Indication | Notes on Use |
|---|---|---|---|---|---|
| Wegovy | 0.25 mg weekly | Every 4 weeks: 0.5 → 1 → 1.7 → 2.4 mg | 2.4 mg weekly | Chronic weight management | FDA-approved for obesity |
| Zepbound | 2.5 mg weekly | Every 4 weeks: 5 → 7.5 → 10 → 12.5 → 15 mg | 15 mg weekly | Chronic weight management | Dual agonist, often stronger effects |
| Ozempic | 0.25 mg weekly | Every 4 weeks: 0.5 → 1 → 2 mg | 2 mg weekly | Type 2 diabetes | Off-label for weight common |
| Trulicity | 0.75 mg weekly | After 4 weeks: 1.5 mg, then up to 4.5 mg | 4.5 mg weekly | Type 2 diabetes | Simpler escalation |
| Victoza/Saxenda | 0.6 mg daily (Victoza) | Weekly: 1.2 mg → 1.8 mg (or 3 mg for Saxenda) | 3 mg daily (Saxenda) | Diabetes/Weight | Daily injection |
| Rybelsus | 3 mg daily | After 30 days: 7 mg → 14 mg | 14 mg daily | Type 2 diabetes | Oral option, take on empty stomach |
This comparison highlights differences in escalation speed and maximum doses. Dual agonists like tirzepatide frequently achieve higher weight reductions in studies.
Managing Side Effects During Titration
Gastrointestinal symptoms like nausea peak during dose increases but often subside. Eating smaller meals, avoiding fatty foods, and staying hydrated help ease discomfort. Providers may extend intervals if needed.
Injection site reactions remain mild with proper technique. Rotate sites and use ice if tender. Serious effects like severe abdominal pain require immediate medical attention.
Hydration and fiber intake prevent constipation. Over-the-counter remedies may assist under guidance. Tracking symptoms aids provider adjustments.
Factors Affecting Dosing Decisions
Tolerance varies—sensitive patients may need slower ramps. Strong response at lower doses sometimes allows maintenance there. Weight plateaus prompt evaluation for escalation.
Comorbidities influence choices; kidney function affects certain options. Age and concurrent medications require monitoring. Providers tailor based on labs and feedback.
Lifestyle adherence enhances perceived efficacy. Diet and movement support results at any level. Regular check-ins optimize the process.
Tips for Following Your GLP-1 Dosing Schedule
Inject on the same day each week for routine. Set reminders to avoid missed doses. Use a journal to log injections and symptoms.
Prepare meals ahead to manage appetite changes. Stay active with gentle walks to complement effects. Report concerns promptly for timely tweaks.
Attend follow-ups to review progress. Celebrate incremental improvements. Consistency drives sustainable outcomes.
Monitoring Progress on GLP-1 Therapy
Track weight monthly and note energy levels. Blood work checks metabolic markers every few months. Providers assess if current dose suffices.
Plateaus may signal need for lifestyle review or dose adjustment. Long-term use maintains benefits for many. Mental health support addresses any challenges.
Adjustments occur collaboratively. Patience through titration leads to rewarding results.
Who Benefits from These Dosing Protocols
Adults with obesity (BMI 30+) or overweight with conditions qualify for weight-approved options. Those with type 2 diabetes gain glycemic and weight advantages. Motivated individuals committed to changes succeed best.
Providers screen for thyroid history or pancreatitis risks. Personalized plans ensure safety. These protocols suit broad populations under supervision.
Summary
GLP-1 dosing charts feature gradual titration to reach effective maintenance while minimizing side effects. Wegovy escalates to 2.4 mg weekly, Zepbound to 15 mg, with similar patterns for other agonists. The comparison table outlines starting doses, steps, and maxima across brands. Benefits include appetite control and significant weight loss when paired with habits. Providers guide adjustments based on tolerance and response. These structured schedules support safe, effective management for diabetes and obesity.
FAQ
What is the typical starting dose for GLP-1 medications?
Most begin low—0.25 mg weekly for semaglutide options like Wegovy or Ozempic, and 2.5 mg for tirzepatide like Zepbound. This minimizes initial nausea. Increases occur every four weeks.
How long does it take to reach the full dose?
Titration usually spans 16-20 weeks. Semaglutide reaches 2.4 mg around month five, tirzepatide up to 15 mg similarly. Gradual steps improve tolerance.
Can I skip titration steps if I feel fine?
Providers rarely accelerate unless side effects stay minimal. Standard schedules prioritize safety. Self-adjusting risks complications—always consult first.
What if I miss a dose?
Resume at the current dose within five days for weekly meds. If longer, ask your provider about restarting or lowering. Consistency maintains steady effects.
Are higher doses always necessary for weight loss?
Not always—some achieve good results at mid-levels. Higher doses often yield more loss but may increase side effects. Titration finds your optimal balance.
How do side effects change during dose increases?
They may temporarily worsen with each step but generally improve. Eating light and hydrating helps. Providers offer support or pauses if needed.
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