Dupixent (dupilumab) treats conditions like atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps. It comes as prefilled syringes or pens for subcutaneous injection. Proper storage keeps the medication effective and safe.
Refrigeration protects Dupixent from degradation. The drug requires cold conditions for long-term stability. Many users face situations where refrigeration isn’t immediate, such as travel or power outages.
This article explains official storage rules for Dupixent. It covers fridge requirements, room temperature allowances, and disposal guidelines. Understanding these helps maintain the drug’s potency.
Recommended Refrigeration Storage
Dupixent should stay refrigerated at 36°F to 46°F (2°C to 8°C). Keep it in the original carton to shield from light. This maintains stability until the expiration date.
Store away from the freezer compartment. Freezing damages the protein-based drug. Never shake or expose to heat sources.
Refrigerator storage suits ongoing use. Place pens or syringes in the main compartment, not the door. Consistent cold prevents breakdown of active ingredients.
Room Temperature Allowance
Dupixent can remain at room temperature up to 77°F (25°C) for a maximum of 14 days. This flexibility helps during travel or short outages. Do not exceed this temperature or duration.
Once removed from the fridge, use within 14 days. Discard after this period even if unused. This rule applies to both syringes and pens.
The allowance supports convenience without compromising safety. Track removal date to avoid errors. Return to fridge only if within guidelines.
What Happens If Dupixent Exceeds Limits
Leaving Dupixent out longer than 14 days reduces effectiveness. Discard immediately to avoid reduced benefits. Temperature over 77°F accelerates degradation.
Do not re-refrigerate after room temperature exposure beyond short periods. This may cause instability. Always follow single-use allowance.
Exposure to direct sunlight or heat shortens viability. Protect from these elements. Proper handling preserves therapeutic value.
Traveling with Dupixent
Travel often requires temporary room temperature storage. Use insulated bags with ice packs for longer trips. This keeps within safe ranges.
Airlines permit Dupixent in carry-on luggage. Declare it during security checks. Carry original packaging for identification.
Plan doses around travel. Use room temperature allowance wisely. This ensures uninterrupted treatment.
Tips for Safe Dupixent Storage During Travel
- Pack in a cooler with gel packs for flights.
- Label with removal date from fridge.
- Avoid checked baggage for temperature control.
- Carry extra doses for delays.
Why Proper Storage Matters
Dupixent is a biologic made of proteins. Heat or improper conditions denature these proteins. This lowers ability to block inflammatory signals.
Consistent cold storage preserves molecular structure. Room temperature allowance accounts for real-life needs. It balances practicality with efficacy.
Following guidelines maximizes treatment outcomes. Proper care reduces waste and costs. It supports consistent symptom control.
Comparing Storage Options
Refrigeration offers longest stability. Room temperature provides short-term flexibility. Freezing or heat destroys the drug.
Original carton protects from light degradation. Avoid clear containers. This maintains integrity over time.
Different formats share identical rules. Syringes and pens follow same protocols. Consistency simplifies management.
| Storage Condition | Temperature Range | Maximum Duration | Action After Limit | Key Protection Notes |
|---|---|---|---|---|
| Refrigerated | 36°F to 46°F (2°C to 8°C) | Until expiration | None (keep cold) | Original carton, no freezing |
| Room Temperature | Up to 77°F (25°C) | 14 days max | Discard unused | No re-refrigeration after |
| Exposed to Heat/Sun | Above 77°F (25°C) | Immediate discard | Do not use | Avoid direct light/heat |
| Frozen | Below 36°F (2°C) | Discard immediately | Do not thaw/use | Never freeze |
Handling Missed or Delayed Doses
If delayed due to storage issues, consult your prescriber. Use within 14 days of removal. Resume schedule after administration.
Do not double dose to compensate. This risks side effects. Maintain regular timing when possible.
Track injections carefully. Use calendars or apps for reminders. This prevents storage-related interruptions.
Disposal of Unused Dupixent
Discard after 14 days at room temperature. Use sharps containers for needles. Follow local regulations for biologics.
Do not flush or trash improperly. Pharmacies offer disposal programs. This protects environment and safety.
Expired or damaged product requires immediate disposal. Check appearance before use. Clear to pale yellow is normal.
Common Storage Mistakes to Avoid
Leaving in hot cars ruins Dupixent quickly. Avoid trunks or direct sun. This shortens usable time drastically.
Shaking vials damages contents. Handle gently. Freezing from door placement occurs often.
Forgetting removal date leads to waste. Mark calendar upon taking out. This simple step saves medication.
Traveling Tips and Considerations
International travel requires checking local storage rules. Carry prescription copies. This aids customs clearance.
Power outages pose risks. Use coolers as backup. Plan for potential delays.
Long trips may need pharmacy coordination. Refill strategically. This maintains continuous supply.
Understanding Dupixent Formulation
Dupixent is a monoclonal antibody. It targets IL-4 and IL-13 pathways. Storage preserves this delicate structure.
Prefilled formats simplify home use. No mixing required. This enhances adherence.
Biologics demand careful handling. Temperature excursions affect potency. Guidelines protect therapeutic value.
Future Storage Considerations
Policies remain stable based on current data. Manufacturers monitor stability. Updates come from ongoing studies.
Patient education focuses on compliance. Resources provide reminders. This supports effective use.
Stay informed through official channels. Prescribing info updates occasionally. This ensures current practices.
Conclusion
Dupixent requires refrigeration for long-term storage but allows up to 14 days at room temperature up to 77°F. Following these rules maintains effectiveness and safety. Proper handling ensures consistent treatment benefits.
FAQ
How long can Dupixent stay out of the refrigerator?
Dupixent can remain at room temperature up to 77°F (25°C) for a maximum of 14 days. Use within this period or discard. Do not exceed 77°F or return to fridge after extended exposure.
What happens if Dupixent is left out longer than 14 days?
Discard immediately if left out over 14 days. Effectiveness decreases and safety cannot be guaranteed. Do not use or re-refrigerate damaged product.
Can Dupixent be stored at room temperature permanently?
No, long-term storage requires refrigeration at 36°F to 46°F. Room temperature is only for up to 14 days when necessary. Keep in original carton to protect from light.
Should Dupixent be protected from light during storage?
Yes, store in the original carton to shield from light. Light exposure can degrade the medication. This applies to both fridge and room temperature periods.
What temperature is too hot for Dupixent?
Do not store above 77°F (25°C). Higher temperatures accelerate breakdown. Avoid heat sources, direct sunlight, or hot environments like cars.
Can Dupixent be frozen?
No, never freeze Dupixent. Freezing damages the biologic structure. Discard if accidentally frozen and do not thaw for use.
How should I handle Dupixent during travel?
Use insulated coolers with ice packs for longer trips. Keep in carry-on luggage. Use the 14-day room temperature allowance if refrigeration isn’t available.
What should I do if Dupixent is exposed to heat?
Discard if exposed above 77°F or for over 14 days. Contact your pharmacist or prescriber for replacement. Do not use potentially compromised medication.
Dr. Usman is a medical content reviewer with 12+ years of experience in healthcare research and patient education. He specializes in evidence-based health information, medications, and chronic health topics. His work is based on trusted medical sources and current clinical guidelines to ensure accuracy, transparency, and reliability. Content reviewed by Dr. Usman is for educational purposes and does not replace professional medical advice.