What are the Serrapeptase side effects on the liver?

Serrapeptase side effects liver

Serrapeptase is a proteolytic enzyme which means it breaks down proteins into smaller components called amino acids. It is extracted from the silkworm and is widely known for its potential health benefits, from reducing inflammation to alleviating pain.

However, like any other substance, there are some things to consider. It’s important to understand the side effects of this enzyme on one of our body’s most vital organs: the liver.

In this article, we discuss the potential side effects of Serrapeptase on the liver, providing a detailed and comprehensive analysis. We also give some tips to minimize these side effects and the overall health benefits of Serrapeptase.

About Serrapeptase

Serrapeptase is a proteolytic enzyme that is extracted from the Serratia species of bacteria found in the digestive system of silkworms. The silkworm uses this enzyme to dissolve its cocoon as it transforms into a moth.

Serrapeptase, a dietary supplement used in Europe and Japan by Takeda Chemical Industries for centuries, offers a lot of health benefits. These include pain and swelling reduction, improved cardiovascular health, and treatment of sinusitis and bronchitis.

Since the 1980s, it has been an alternative medical treatment to reduce inflammation and discomfort caused by surgery and illness, without causing any severe side effects.

In fact, researchers in Europe and Japan have actually suggested that serrapeptase is the most potent proteolytic enzyme for reducing inflammation.

Our bodies’ natural enzymes are unable to break down proteins as effectively as serrapeptase does. That’s why we take supplements containing this enzyme.

Usage Of Serrapeptase

Serrapeptase is commonly used for conditions like:

  • rheumatoid arthritis
  • sinusitis
  • bronchitis
  • back pain
  • reduces the risk of blood clots
  • aid in pain management, especially post-surgery or injury
  • respiratory diseases
  • swelling or inflammation

However, there isn’t enough evidence to support these uses.

How does Serrapeptase affect the liver?

The side effects of serrapeptase on the liver are not fully understood, but studies show its both positive and negative impacts. One of its main functions is to break down proteins that can cause inflammation and slow down healing.

On the beneficial side, a study published by the NIH suggests that Serrapeptase can help reduce post-operative swelling, a common issue that can strain the liver.

However, there have been reports of elevated liver enzymes in some people who take Serrapeptase, indicating possible liver stress or damage (as reported in BMJ Case Reports).

These potential liver complications appear to be rare and usually resolve after discontinuing the supplement. However, it’s important to monitor and use caution, especially for those with existing liver conditions or taking other medications that may affect the liver.

Related: Does Serrapeptase Cause Hair Loss? Complete Guide

What are the Serrapeptase side effects on the liver?

Serrapeptase is generally considered safe for consumption, but some people experience its side effects on the liver. The most common side effects include:

  • Mild elevation of liver enzymes: This is the most common side effect of Serrapeptase on the liver. It’s usually temporary and resolves itself once the supplement is discontinued.
  • Increased Bleeding Risk: As Serrapeptase thins the blood, it may increase the risk of bleeding. This may indirectly affect the liver, especially in people with existing liver conditions.
  • Liver discomfort or pain: Some people have reported discomfort or pain in the liver area, which may be due to the liver processing the enzyme. If this occurs, usage should be discontinued, and medical advice should be sought.
  • Potential liver damage: It’s rare but there have been some reports of potential liver damage associated with Serrapeptase use. It seems to be more common in those with pre-existing liver disease, or those taking other medications like statins or blood thinners, that can affect the liver.
  • Allergic reactions: In some cases, an individual may have an allergic reaction to Serrapeptase which causes inflammation that can affect the liver.
  • Interactions with other medications: Serrapeptase may interact with some medications, like those that slow blood clotting including Anticoagulants or Antiplatelet drugs, which can increase the risk of liver complications.
  • Potential for Liver Toxicity: Although rare, there have been reports of Serrapeptase causing liver toxicity in some people. The symptoms include jaundice, fatigue, abdominal pain, and a feeling of malaise.

Note that these side effects are very rare and not commonly seen. Serrapeptase is generally considered safe to use.

How can I minimize the potential side effects?

There are several ways to minimize the potential side effects of Serrapeptase on the liver. Here are some of them:

  1. Start with a low dosage: It’s important to start with a low dosage of Serrapeptase and gradually increase the dosage if necessary. This allows your body to adjust to the enzyme and minimize the risk of side effects.
  2. Always take with a meal: Taking Serrapeptase with a meal can help to minimize the risk of gastrointestinal side effects and reduce the burden on your liver.
  3. Monitor your liver health: Periodic liver function tests are recommended to monitor the effect of Serrapeptase on your liver, especially if you have a pre-existing liver condition like hepatitis or cirrhosis or are taking other medications that may affect the liver.
  4. Discontinue use if side effects occur: If you experience side effects like liver discomfort or an allergic reaction, discontinue use and consult your healthcare provider.

Using Serrapeptase Benefits

Benefits of Using Serrapeptase

Serrapeptase is a supplement that offers a wide range of health benefits. It goes beyond protein digestion and has a significant impact on various aspects of human health.

Supports Respiratory Health

Serrapeptase supports respiratory health by breaking down excess proteins and mucus. It can be a helpful option for respiratory conditions like bronchitis, sinusitis, and asthma. It helps to reduce chest congestion, cough, and shortness of breath, offering respite by improving airway passage and the ability to breathe more comfortably.

Moreover, it is also used to manage chronic obstructive pulmonary disease (COPD), a condition characterized by the blockage of airflow, which makes breathing difficult.

Sinusitis Relief

If you’re dealing with Sinusitis, a condition marked by inflammation and swelling of the sinuses, Serrapeptase can help bring relief by encouraging the drainage of extra mucus and fluids. It can also help unclog nasal passages and reduce pressure in the head.

A thorough review analyzed 24 studies that showed the beneficial effects of serrapeptase in reducing inflammation in different conditions, including sinusitis.

Reduces Inflammation

One of the main benefits of Serrapeptase is its ability to reduce swelling and inflammatory responses after surgery. A study published in the International Journal of Surgery showed that patients who take Serrapeptase after surgery experienced less facial swelling post-operation compared to those who were administered a placebo. This shows that Serrapeptase can be a beneficial addition to postoperative care, reducing discomfort and hastening recovery time.

Arthritis Relief

Serrapeptase is also believed to have beneficial effects on inflammatory conditions like arthritis. This enzyme can break down proteins that trigger inflammation and promote healing.

A research article published in the Journal of Rheumatology showed that Serrapeptase led to a significant reduction in symptoms of carpal tunnel syndrome, which include pain and inflammation and is often a result of rheumatoid arthritis.

The study concluded that Serrapeptase can be an effective alternative to traditional NSAIDs (Nonsteroidal anti-inflammatory drugs) with fewer side effects.

Aids in Pain Management

This enzyme has anti-inflammatory effects that can help to alleviate different types of pain. It is commonly used to manage pain and swelling following minor surgeries, as well as for conditions like arthritis and sinusitis.

Serrapeptase works by breaking down proteins in the body, reducing inflammation, and promoting fluid drainage. This helps alleviate pain and inflammation, providing relief. Studies show that Serrapeptase can reduce post-operative cheek swelling and pain after wisdom teeth removal, indicating its potential for broader applications in pain management.

Promotes Cardiovascular Health

Serrapeptase also has potential benefits for cardiovascular health. It can help break down those unwanted deposits in the arteries, which means better circulation and a lower risk of heart disease. It also has anti-inflammatory effects, which may help reduce the risk of heart attacks and strokes.

A study found that Serrapeptase could help lower blood pressure and improve lipid profiles. This makes it a potential therapy for hypertension and dyslipidemia.

When Taking Serrapeptase What To Avoid?

When taking Serrapeptase, it’s crucial to avoid certain things to ensure its effectiveness and your safety. Here are some of them:

  1. Serrapeptase should be taken with a meal to prevent gastrointestinal side effects and to maximize absorption.
  2. Avoid combining Serrapeptase with other blood-thinning medications such as Warfarin.
  3. Alcohol can increase the risk of liver damage, especially when taking Serrapeptase. It’s best to limit or avoid alcohol while using this supplement.
  4. Consult your doctor before taking Serrapeptase, especially if you are pregnant or nursing.
  5. Serrapeptase might interfere with blood clotting, so it might increase bleeding in people with bleeding disorders.
  6. It’s advised to stop taking Serrapeptase at least 2 weeks before a scheduled surgery.
  7. If you’ve had an allergic reaction to Serrapeptase in the past, it’s important to avoid it and inform your healthcare provider.


In conclusion, Serrapeptase is a versatile enzyme supplement with many health benefits. It supports respiratory health, relieves sinusitis and arthritis, reduces inflammation, helps with pain management, and promotes cardiovascular health.

When it comes to liver health, caution is advised. This is especially important for those with existing liver conditions or those taking medications that may affect the liver. Just like any other supplement, it is important to consult your provider before starting Serrapeptase and to be mindful of any potential side effects.


Does Serrapeptase Work for Weight Loss?

No, Serrapeptase does not work for weight loss. It is an enzyme that has anti-inflammatory effects and is primarily used for managing pain and inflammation, among other health benefits. It doesn’t contribute to weight loss. However, due to its anti-inflammatory properties, it may indirectly support overall health and well-being in a holistic weight loss plan with exercise and a balanced diet.

When Should You Not Take Serrapeptase?

Serrapeptase should not be taken by people with bleeding disorders, those about to undergo surgery, pregnant or nursing women, individuals taking blood-thinning medications or anyone who’s had an allergic reaction to it in the past.

Is Serratiopeptidase a Muscle Relaxant?

No, Serratiopeptidase is not a muscle relaxant. It’s an anti-inflammatory and analgesic medicine, which can indirectly help to alleviate muscle pain or discomfort. However, it doesn’t have the muscle relaxant effects commonly seen in medications that reduce muscle tension or spasms.

How Do I Know if Serrapeptase is Working?

To know whether Serrapeptase is working, you need to closely monitor your symptoms. If you’re taking it for inflammation or pain relief, you should notice a decrease in symptoms over time. This might include reduced swelling, less pain, or improved mobility in the case of arthritis. For conditions like sinusitis, you may experience less congestion or discomfort.

Is Serrapeptase Safe to Take Daily?

Yes, Serrapeptase is generally safe to take daily, as long as it is taken at the recommended dosage. However, everyone is unique, and what works for one person may not work for someone else. So, it’s always important to check with your doctor before trying any new supplements.




The information provided in this article is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Don’t ignore professional medical advice or put off seeking it just because of something you read here. Although we aim to offer precise and current information, we do not guarantee its completeness, accuracy, reliability, suitability, or availability for any purpose. Using the information in this document is at your own risk. We are not responsible for any losses or damages caused by our content.

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