Trulicity and Mounjaro are popular injectable medications used to manage type 2 diabetes. Both help control blood sugar levels and often lead to some weight loss. Many people compare them when looking for effective treatment options.
These drugs belong to a class of medications that mimic hormones in the body to improve insulin use and slow digestion. Doctors often prescribe them alongside diet and exercise. Understanding their differences helps patients make informed choices with their healthcare providers.
This article breaks down how Trulicity and Mounjaro compare in key areas like effectiveness, dosing, side effects, and cost. The goal is to provide clear information for anyone managing type 2 diabetes.
What Is Trulicity?
Trulicity contains dulaglutide, a GLP-1 receptor agonist. It works by helping the pancreas release insulin when blood sugar rises. It also slows stomach emptying to reduce appetite.
The medication has been available since 2014 and is approved for adults and children aged 10 and older with type 2 diabetes. It also lowers the risk of major heart events in adults with heart disease.
Trulicity comes in a prefilled pen for once-weekly injections. Many patients find it convenient because it requires no mixing or complicated setup.
What Is Mounjaro?
Mounjaro contains tirzepatide, a dual GIP and GLP-1 receptor agonist. This means it targets two hormones instead of one. The dual action often leads to stronger effects on blood sugar and weight.
Approved by the FDA in 2022, Mounjaro is for adults with type 2 diabetes. It is used along with diet and exercise to improve glycemic control.
Like Trulicity, Mounjaro is given as a weekly injection via a pen. Patients usually start at a low dose and increase gradually to minimize side effects.
How Do They Work?
Both medications enhance the body’s natural response to food intake. They boost insulin secretion in a glucose-dependent way. This reduces the risk of low blood sugar episodes.
They also slow gastric emptying, which helps people feel full longer. This contributes to reduced calorie intake and modest weight loss in many users.
Mounjaro’s dual mechanism provides an extra layer of action through GIP receptor activation. This often results in more noticeable improvements compared to single-action GLP-1 drugs like Trulicity.
Key Differences at a Glance
| Aspect | Trulicity (Dulaglutide) | Mounjaro (Tirzepatide) |
|---|---|---|
| Drug Class | GLP-1 receptor agonist | Dual GIP/GLP-1 receptor agonist |
| FDA Approval Year | 2014 | 2022 |
| Approved Ages | Adults & children 10+ | Adults only |
| Starting Dose | 0.75 mg weekly | 2.5 mg weekly |
| Max Dose | 4.5 mg weekly | 15 mg weekly |
| Heart Protection | Approved to reduce CV events | Non-inferior in recent trials |
| Typical A1C Drop | 1–1.5% | 1.5–2.4% |
| Average Weight Loss | 2–6 lbs (clinical trials) | 15–22 lbs (higher doses) |
| List Price (approx) | $1,000–$1,400 per month | $1,100–$1,500 per month |
This table highlights the main distinctions based on clinical data and prescribing information. Actual results vary by individual.
Effectiveness for Blood Sugar Control
Clinical studies show Mounjaro often outperforms Trulicity in lowering A1C levels. In head-to-head trials, patients on Mounjaro achieved greater reductions, sometimes exceeding 2%.
Trulicity provides solid A1C improvements, typically in the 1% to 1.5% range. It remains a reliable choice for many patients, especially those with established heart disease.
The SURPASS trials and recent SURPASS-CVOT study confirm Mounjaro’s edge in glycemic control. However, both drugs work well when combined with lifestyle changes.
Weight Loss Comparison
Weight loss is a common benefit of these medications, though neither is primarily approved for that purpose. Mounjaro tends to produce more significant results due to its dual action.
Patients on higher doses of Mounjaro have reported 15–22 pounds of weight loss in trials. Trulicity usually leads to more modest losses, around 2–6 pounds over similar periods.
Many people switch to Mounjaro when seeking greater weight reduction alongside diabetes management. Individual factors like starting weight and adherence play a big role.
Dosing and Administration
Trulicity starts at 0.75 mg once weekly, with possible increases to 4.5 mg. The pen is straightforward, and some doses can start at a therapeutic level.
Mounjaro begins at 2.5 mg for four weeks, then increases in 2.5 mg steps every four weeks up to 15 mg. This gradual titration helps reduce gastrointestinal side effects.
Both are injected under the skin in the abdomen, thigh, or upper arm. Rotation of sites is recommended to avoid irritation.
Common Side Effects
Gastrointestinal issues are the most frequent complaints with both drugs. These often occur during the first weeks or after dose increases.
- Nausea – Very common, especially early on
- Diarrhea – Frequent but usually mild
- Vomiting – Can happen but tends to improve
- Decreased appetite – Helps with weight loss but may cause fatigue
- Abdominal pain – Reported by some users
Side effects generally lessen over time as the body adjusts. Eating smaller meals and staying hydrated can help manage them.
Serious Side Effects and Warnings
Both carry a boxed warning for possible thyroid tumors based on animal studies. Human risk remains unclear, but monitoring is advised.
Pancreatitis, gallbladder problems, and severe allergic reactions are rare but serious. Kidney issues can occur, particularly in dehydrated patients.
Patients with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should avoid these drugs. Always discuss personal risks with a doctor.
Cost and Insurance Coverage
Without insurance, both medications cost around $1,000 to $1,500 per month. Prices vary by pharmacy and location.
Many insurance plans cover them for type 2 diabetes, though prior authorization is often required. Manufacturer savings cards can lower out-of-pocket costs significantly.
Mounjaro sometimes faces higher copays due to its newer status. Checking with pharmacies or using discount programs helps reduce expenses.
Who Might Benefit More from Each?
Trulicity may suit patients needing proven heart protection or those treating younger patients. Its longer track record offers reassurance for some.
Mounjaro often appeals to those prioritizing maximum blood sugar control and weight loss. It is a strong option when other treatments fall short.
The best choice depends on individual health goals, medical history, and how the body responds. A healthcare provider can guide the decision.
Conclusion
Trulicity and Mounjaro are effective tools for managing type 2 diabetes, with Mounjaro generally showing stronger results in blood sugar control and weight loss. Trulicity offers established cardiovascular benefits and is suitable for a broader age range. Both require careful monitoring for side effects and regular follow-ups. Talk to your doctor to determine which aligns best with your needs and lifestyle.
FAQ
Which one is more effective for lowering A1C?
Mounjaro typically lowers A1C more than Trulicity, often achieving reductions of 1.5% to over 2%. Trulicity usually reduces A1C by 1% to 1.5%. Clinical trials like SURPASS show Mounjaro’s advantage in glycemic control.
Is Mounjaro better than Trulicity for weight loss?
Mounjaro generally leads to greater weight loss, with many patients losing 15–22 pounds at higher doses. Trulicity supports more modest losses of 2–6 pounds. The dual mechanism in Mounjaro contributes to this difference.
What are the main side effects of each?
Both commonly cause nausea, diarrhea, vomiting, and decreased appetite. These are usually mild and improve over time. Serious risks include pancreatitis and thyroid concerns, though rare.
Can children use Trulicity or Mounjaro?
Trulicity is approved for children aged 10 and older with type 2 diabetes. Mounjaro is only approved for adults. Pediatric use should always involve specialist guidance.
How do the costs compare without insurance?
Both cost roughly $1,000 to $1,500 per month without coverage. Insurance and savings programs can lower this significantly. Mounjaro may have slightly higher list prices in some cases.
Dr. Usman is a medical content reviewer with 12+ years of experience in healthcare research and patient education. He specializes in evidence-based health information, medications, and chronic health topics. His work is based on trusted medical sources and current clinical guidelines to ensure accuracy, transparency, and reliability. Content reviewed by Dr. Usman is for educational purposes and does not replace professional medical advice.