Does The Second Dose Of Suprep Work Faster?

Does The Second Dose Of Suprep Work Faster

When it comes to bowel preparation for a colonoscopy, the Suprep Bowel Prep Kit is a commonly prescribed medication. The process usually involves taking two doses, and many patients raise the question: “Does the second dose of Suprep work faster?”

Understanding how this medication functions and how the body reacts to it is important, especially for those who are about to undergo this important procedure.

This article aims to provide an insightful exploration into the workings of Suprep and how it may differ between the first and second doses.

How does Suprep work?

The active ingredients in Suprep, sodium sulfate, potassium sulfate, and magnesium sulfate, function together to create an osmotic effect in the intestines.

This mixture is poorly absorbed by the gastrointestinal (GI) tract, causing these salts to draw water into your GI tract. This softens the stool, making it easier to pass.

Each dose should be followed by drinking an ample amount of water to maintain hydration and aid in the osmotic effect. This dual dosing regimen and hydration process help to ensure the colon is adequately cleaned for clear visibility during the colonoscopy.

Understanding The Side Effects of Suprep

Like any medication, Suprep is not free from potential side effects.

Common side effects include:

  • nausea
  • abdominal discomfort
  • bloating, or feelings of fullness
  • stomach pain
  • vomiting

However, these side effects are usually temporary and should go away as your body gets used to the medication.

Additional severe side effects can include vomiting, intense abdominal pain, or bloody stools In cases of significant loss of body fluids, symptoms may include reduced or no urination, painful bloating or stomach cramps, headaches, seizures, and irregular heartbeat.

Inform your healthcare provider if you have heart or kidney issues before using Suprep, as the medication can affect electrolyte levels, which if unchecked, can cause heart or kidney problems.

Does the second dose of Suprep work faster?

Yes, based on patient experiences and how the medication works in the body, it seems that the second dose of Suprep often works faster than the first one.

This effect may be due to the body’s already heightened state of bowel activity after the first dose. Essentially, the first dose “prepares” the bowel for the procedure, and the second dose then speeds up the process, leading to a faster response.

However, people’s responses can vary greatly based on factors like metabolism, the food consumed leading up to the procedure, and individual hydration levels.

Remember, that both doses are necessary for a thorough colon cleanse ahead of the colonoscopy, irrespective of how quickly the second dose appears to work. Always follow your doctor’s instructions and reach out right away if you have any concerns or experience severe side effects.

Related: How Long Do You Poop After Second Dose Of Suprep?

The Process of Bowel Cleansing with Suprep

The bowel cleansing process with Suprep involves a few key steps to ensure that the colon is thoroughly cleaned out for the colonoscopy.

  1. Preparation: Before starting with the Suprep, it is important to follow your doctor’s recommendations about diet and fluid intake. You may be advised to avoid certain foods like popcorn, seeds(flax, sunflower, quinoa), beans, nuts, multigrain bread, salad/vegetables, or fresh and dried fruit to stay hydrated.
  2. Taking the First Dose: The first dose of Suprep is usually taken the night before the colonoscopy. After drinking the Suprep solution, be sure to drink the recommended amount of water to help with the cleansing process.
  3. Second Dose: The second dose of Suprep is usually consumed on the morning of the procedure. Just like with the first dose, it’s crucial to drink ample water after consuming the Suprep solution.
  4. What to Expect: Following each dose, you can expect to have multiple bowel movements. These are likely to become more frequent and will become clearer as your colon is cleansed.
  5. Staying Comfortable: During this process, it’s important to stay as comfortable as possible. Staying near a bathroom, keeping hydrated, and using soft toilet paper or wet wipes can all help.
  6. Contacting Your Healthcare Provider: If you experience severe side effects, like intense abdominal pain, bloody stools, or symptoms of significant fluid loss like reduced urination or severe cramping, contact your doctor immediately.

Remember, the goal of Suprep and the associated bowel preparation is to thoroughly clean your colon. This preparation allows the doctor to have the clearest possible view during your colonoscopy, which helps in accurate diagnosis and effective treatment.

Tips for Taking Suprep

Here are some tips to make the process of taking Suprep more comfortable and effective:

  • Stay Hydrated: Suprep can cause dehydration due to increased bowel movements. So it’s important to drink enough water or clear liquids to replace the fluids lost during bowel preparation.
  • Chill the Solution: Some patients find the taste of Suprep to be unpleasant. Chilling it in the refrigerator before consumption can help to improve the taste.
  • Use a Straw: Drinking the solution with a straw can help it bypass some of your taste buds, making it more palatable.
  • Plan Your Day: As Suprep triggers frequent bowel movements, it’s best to plan your day accordingly. Stay at home, and keep a bathroom nearby.
  • Comfort Measures: Using soft tissue or wet wipes instead of regular toilet paper can help prevent discomfort due to frequent bowel movements.
  • Monitor Your Stool: Your stool should become clear or light yellow after taking Suprep. If it’s not, contact your healthcare provider.


In conclusion, proper bowel preparation with Suprep is crucial to the success and accuracy of a colonoscopy. While the process may seem challenging, understanding each step, being aware of potential side effects, and following your doctor’s instructions can make it manageable. Whether it’s hydrating properly, chilling the solution for taste, monitoring your stool changes, or immediately alerting your doctor of severe side effects, each action helps cleanse your colon and improves the accuracy of your colonoscopy diagnosis.


Is the second dose of Suprep necessary?

Yes, the second dose of Suprep is absolutely necessary. Both doses of the medication work together to thoroughly cleanse the colon before a colonoscopy. Even though the second dose often works faster than the first, it does not mean it is less important.Skipping the second dose may leave remnants in the colon, obstructing the view during the colonoscopy and possibly causing inaccurate results.

How long does the second dose of Suprep last?

The second dose of Suprep generally starts working in 30 minutes to an hour, with its effects lasting for a few hours up until the colonoscopy. However, the exact duration can vary depending on factors like metabolism, hydration, and diet prior to the procedure. It’s crucial to remain near a bathroom during this time, as the bowel movements can be sudden and frequent.

What happens after the second dose of Suprep?

After taking the second dose of Suprep, you should continue to experience frequent bowel movements. These bowel movements are expected to be clear or light yellow which shows that your colon is effectively cleansed. It’s vital to continue consuming clear liquids to remain hydrated. Don’t consume any solid food until after your colonoscopy.



The information provided in this article is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Don’t ignore professional medical advice or put off seeking it just because of something you read here. Although we aim to offer precise and current information, we do not guarantee its completeness, accuracy, reliability, suitability, or availability for any purpose. Using the information in this document is at your own risk. We are not responsible for any losses or damages caused by our content.

Sharing is Caring

Leave a Comment

Related Articles