Can You Take Advil With Paxlovid? Understanding Drug Interactions

Can You Take Advil With Paxlovid

Understanding how different medications interact is important to safeguarding your health. If you’ve been prescribed Paxlovid for COVID-19 treatment, you might be wondering if it’s safe to take with over-the-counter drugs like Advil.

It’s a valid and important question. After all, many of us rely on such meds for relief from common ailments like headaches or fevers.

In this article, we will discuss the science behind drug interactions, specifically focusing on the co-administration of Paxlovid and Advil. Our aim is to provide you with straightforward, scientifically-backed information to help you make informed choices about your health.

What is Paxlovid and its purpose?

Paxlovid, also known as PF-07321332, is a new antiviral medicine made by Pfizer. It helps treat mild-to-moderate COVID-19 in adults who are at risk of getting worse.

It works by stopping a specific enzyme that the SARS-CoV-2 virus (which causes COVID-19) needs to reproduce inside a person’s body.

By doing so, Paxlovid can effectively reduce the severity of the illness and prevent hospitalizations.

The medicine is also accessible to anyone 12 years and older (weighing at least 88 pounds) who has a mild-to-moderate illness and is at a high risk for severe illness, as authorized by the FDA in an Emergency Use Authorization.

Remember, this medication cannot replace getting vaccinated against COVID-19. Make sure to talk to your healthcare provider for advice that suits your situation.

Advil And Its Purpose

Advil is also known by its generic name ibuprofen. It is a commonly used over-the-counter medication. It works by reducing hormones that cause inflammation and pain in the body.

Advil is employed to relieve pain from various conditions like headaches, dental pain, menstrual cramps, muscle aches, or arthritis.

It is also used to reduce fever and alleviate minor aches and pain due to the common cold or flu.

Ibuprofen works by blocking your body’s production of certain natural substances that cause inflammation, helping to decrease swelling, pain, or fever.

However, using it has risks, so always use it in moderation and follow the instructions on the packaging or from your healthcare provider.

Do not take more than your recommended dose. Overuse can lead to gastrointestinal issues, kidney damage, or an increased risk of heart attack or stroke.

Can you take Advil with Paxlovid?

Yes, you can take Advil with Paxlovid, but be careful. Paxlovid has nirmatrelvir and ritonavir that can interact with many other medications, which could cause serious or life-threatening side effects.

FDA recommends that you should tell your healthcare providers about all the medicines you are taking, including over-the-counter drugs and herbal supplements when deciding whether to take Paxlovid.

Do not exceed the recommended dosage and limit its use to when it’s truly needed. Overuse can lead to a variety of health issues, like stomach problems, heart issues, and kidney damage.

Possible interaction of Paxlovid with Advil

You can take Advil and Paxlovid together, but be aware of potential interactions. Paxlovid contains nirmatrelvir and ritonavir, which may interact with other medications and cause serious side effects.

According to the FDA, there is a chance that taking Paxlovid and Advil together could decrease the effectiveness of both drugs. However, to date, there are no studies showing significant interactions between these two medications.

Always consult your healthcare provider before starting new medications. They can offer personalized advice based on your health needs and ensure your safety.

Other Interactions of Paxlovid

Paxlovid, as an antiviral medication, can interact with a lot of other common drugs:

  • Anticoagulants: Paxlovid can increase the levels of anticoagulants like warfarin in your body, which could cause an increased risk of bleeding. Regular monitoring of your INR (International Normalized Ratio) is recommended if you’re on these medications.
  • Cholesterol Drugs (Statins): Certain statins like simvastatin and lovastatin should be avoided while on Paxlovid, as it can increase their concentration in the body, causing side effects like muscle pain and weakness.
  • Heart Rhythm Medications: Paxlovid can interact with drugs like amiodarone and digoxin, used to manage heart rhythm disorders. This may cause changes in your heart rhythm, so close monitoring by your healthcare provider is advised.
  • Antidepressants: Paxlovid may interact with antidepressants like trazodone, causing side effects such as confusion and heart rhythm issues. If you take these medications, your healthcare provider may suggest alternatives or adjust your dosage.
  • Oral Contraceptives: Paxlovid can reduce the effectiveness of hormonal contraceptives, increasing the risk of unplanned pregnancy. Consider using an additional or alternative method of contraception.

Remember, this list is not complete. Always consult with your healthcare provider about potential interactions when starting Paxlovid.

Safety Considerations

Safety first when taking any medication, including Paxlovid. Here are some important safety factors to consider:

1. Allergies: Please be mindful of any allergies you may have to the ingredients in Paxlovid. Allergic reactions can range from mild skin irritations to severe. If you experience hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, seek quick medical attention.

2. Pregnancy & Breastfeeding: If you are pregnant or have any plan, or breastfeeding, consult your healthcare provider before starting Paxlovid. The effects of this medication on pregnant women or nursing infants are still being studied.

3. Liver or Kidney Disease: If you have had liver or kidney disease in the past, be sure to mention this to your doctor.

4. Other Health Conditions: Discuss any other health conditions you have with your healthcare provider before starting Paxlovid. This list includes heart disease, diabetes, HIV, or any other chronic illness.

5. Interactions with Alcohol or Recreational Drugs: It’s not currently known if Paxlovid interacts with alcohol or recreational drugs. But it’s recommended to avoid these substances while on Paxlovid.


In conclusion, the co-administration of Paxlovid and Advil is generally safe, but vigilance is required due to the potential for interactions. When it comes to any medication, it’s important to consider factors like dosage, frequency, and the presence of other health conditions.

Always talk to your doctor before starting new medications to ensure your safety. Health is a personal journey, and our mission is to provide trustworthy and easily understandable information to support you every step of the way.


Can taking Advil worsen COVID-19 symptoms?

There’s no strong evidence that suggests that Advil or other non-steroidal anti-inflammatory drugs (NSAIDs) worsen COVID-19 symptoms. If you’re feeling unwell and considering taking Advil, it’s always best to consult with your healthcare provider.

How long after taking Paxlovid can I take Advil?

You can take Advil at the same time or separately from Paxlovid, as long as you don’t exceed the recommended dosage of either medication. However, you should follow your healthcare provider’s advice when it comes to medication timing and dosages.

Who should not take Paxlovid?

Paxlovid is not recommended for those who are allergic to any of its components. And, those who are taking medications, like Rifampin, St. John’s Wort, or specific seizure and cholesterol medications, are advised against taking Paxlovid due to potential severe interactions. People with certain health conditions, including liver or kidney disease, may also be advised not to take Paxlovid.

Where can I report the side effects of medications?

You can report the side effects directly to the FDA, which helps them monitor the safety of medications and take necessary action. The FDA provides several methods for reporting, including online, by mail, or by phone. Remember, your input is invaluable in ensuring the overall safety of medications for everyone.

What decongestant can I take with Paxlovid?

Over-the-counter decongestants like pseudoephedrine (Sudafed) or phenylephrine (Neo-Synephrine) are generally safe to take with Paxlovid. However, as everyone’s health situation is unique, you should first consult with your doctor before starting this.

Can I take Advil for cold and sinus with Paxlovid?

Yes, it’s generally safe to take Advil Cold and Sinus with Paxlovid. Advil Cold and Sinus contains ibuprofen and pseudoephedrine, both of which are not known to interact negatively with Paxlovid.

Related Medical Information


The information provided in this article is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Don’t ignore professional medical advice or put off seeking it just because of something you read here. Although we aim to offer precise and current information, we do not guarantee its completeness, accuracy, reliability, suitability, or availability for any purpose. Using the information in this document is at your own risk. We are not responsible for any losses or damages caused by our content.

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